تأثیر مکمل‌دهی ویتامین D با دوزهای مختلف بر مقاومت به انسولین در موش‌های صحرایی اوارکتومی‌شده

Background and Aim: Type 2 diabetes mellitus (T2DM) and vitamin D deficiency are both too common during menopause. Since the effect of different doses of vitamin D supplements on blood sugar, insulin concentration&nbsp; and insulin resistance are unknown, the present study aimed at investigating the effects of different doses of the vitamin D supplements on visceral fat, blood sugar, insulin concentration,&nbsp; and insulin resistance in ovariectomized rats. Materials and Methods: In this randomized experimental study, 32 female Wistar rats were divided into 4 equal groups&nbsp; as follows: three groups . that received vitamin D supplements (high, moderate, and low dose) and one control group. After 8 weeks of different doses of vitamin D supplementation plasma concentration of glucose, insulin and HOMA-IR were measured&nbsp; in the three groups. The obtained data&nbsp; was statistically analyzed by means of dependent t-test and ANOVA . at the significance level of P<0.05. Results: After a period of eight-week&nbsp; intervention, body weight, BMI, waist circumference, visceral fat, insulin, blood glucose and HOMA-IR at high, moderate, and low doses of vitamin D supplementation were significantly lower than those in the control group (P<0.05). High dose of vitamin D compared with moderate and low doses significantly caused reduction in insulin, blood glucose, and HOMA-IR (P<0.001 for all three variables). Conclusion: The findings of the current study showed that a high dose of vitamin D causes significant improvements in FPG, insulin, and insulin resistance&nbsp; evaluated by HOMA-IR. It was also found that adding vitamin D supplements can improve glucose control in menopause model of rats.